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Alnylam is committed to providing the healthcare community with balanced, accurate, and high-quality information about our science, therapeutic areas, and products.

More than one search term is recommended to yield the most relevant results. By searching, you confirm that your query is unsolicited. 

For more information about our FDA-approved therapies, please see the Full Prescribing Information:

  • AMVUTTRA® (vutrisiran)
  • GIVLAARI® (givosiran)
  • ONPATTRO® (patisiran)
  • OXLUMO® (lumasiran)

Vutrisiran: Concomitant Use with Diflunisal This link is a pdf
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Standard response letter on the use of vutrisiran with concomitant diflunisal.

Givosiran: Elevations in Blood Homocysteine This link is a pdf
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Standard response letter on givosiran and elevations in blood homocysteine.

Vutrisiran: Use in Patients with Atrial Fibrillation or Flutter This link is a pdf
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Standard response letter on the efficacy of vutrisiran in patients with and without atrial fibrillation or flutter.

Patisiran: APOLLO-B Study This link is a pdf
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Standard response letter on patisiran and the APOLLO-B study, a study evaluating the efficacy and safety of patisiran in patients with ATTR with cardiomyopathy, including both hATTR and wtATTR.

Zilebesiran: ZENITH Study This link is a pdf
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Standard response letter on zilebesiran and the ZENITH study, a phase 3 cardiovascular outcomes trial.

Patisiran: Dosing Schedule This link is a pdf
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Standard response letter on patisiran and the dosing schedule used in clinical trials.

Vutrisiran: Post-Orthotopic Liver Transplant This link is a pdf
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Standard response letter on the exclusion of patients with a history of liver transplant from the HELIOS studies of vutrisiran.

Nucresiran: Phase 1 Study This link is a pdf
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Standard response letter on the phase 1 study of nucresiran.

Vutrisiran: Use in Patients with Heart Transplant This link is a pdf
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Standard response letter on the use of vutrisiran in patients who have received a heart transplant.

Vutrisiran: Dyspnea This link is a pdf
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Standard response letter on vutrisiran and the adverse event of dyspnea.

Givosiran: Use in Patients Without an Identified Porphyria-Related Mutation This link is a pdf
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Standard response letter on the use of givosiran in patients with AHP without an identified porphyria-related genetic mutation.

Vutrisiran: Arthralgia This link is a pdf
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Standard response letter on vutrisiran and the adverse event of arthralgia.

Vutrisiran: Left Ventricular Ejection Fraction in HELIOS-B This link is a pdf
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Standard response letter on vutrisiran and LVEF in the HELIOS-B study.

Zilebesiran: KARDIA-2 Study This link is a pdf
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Standard response letter on zilebesiran and the KARDIA-2 study, a phase 2 study evaluating the efficacy and safety of zilebesiran as add-on therapy in patients with hypertension not adequately controlled by a standard-of-care antihypertensive medication including diuretic (indapamide), CCB (amlodipine), or ARB (olmesartan).

Lumasiran: Pregnancy and Lactation This link is a pdf
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Standard response letter on lumasiran and pregnancy and lactation in the Phase 2 OLE and Phase 3 ILLUMINATE studies.

Givosiran: Timing of Dosing This link is a pdf
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Standard response letter on the timing of dosing of givosiran in the Phase 1 study.

Vutrisiran: Renal-Related Adverse Events This link is a pdf
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Standard response letter on vutrisiran and renal-related adverse events.

Vutrisiran: Vitamin A Levels This link is a pdf
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Standard response letter on vutrisiran and vitamin A levels, including information on supplementation.

Lumasiran Clinical Program Overview This link is a pdf
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This infographic details the lumasiran clinical program (including ILLUMINATE) which investigates the treatment of primary hyperoxaluria type 1 with lumasiran.

Vutrisiran: Ocular Adverse Events This link is a pdf
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Standard response letter on vutrisiran and ocular adverse events in the HELIOS-A and HELIOS-B studies.

Vutrisiran: Changes in Serum TTR Levels This link is a pdf
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Standard response letter on vutrisiran and the changes in serum TTR levels during the HELIOS-A and HELIOS-B studies.

Patisiran: Immunogenicity This link is a pdf
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Standard response letter on patisiran and the percentage of patients in patisiran clinical studies who tested positive for anti-drug antibodies.

Vutrisiran: Injection Site Reactions This link is a pdf
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Standard response letter on vutrisiran and injection site reactions.

Lumasiran: Dosing Regimen This link is a pdf
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Standard response letter on the dosing regimen of lumasiran.

Lumasiran: Injection Site Reactions This link is a pdf
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Standard response letter on the incidence and recommendations for management of injection site reactions.

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Intended for US healthcare professionals. This site is intended to provide balanced, evidence-based information to support scientific exchange. It is not intended to provide medical advice or recommendations for clinical practice.

Information about investigational therapeutics or investigational uses of approved products does not establish the safety or efficacy of these therapeutics or uses, and there is no guarantee of FDA approval.

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