Alnylam & RNAi
Explore a library of educational resources about RNA interference (RNAi), the science behind Alnylam's FDA-approved products and clinical pipeline, and find out more about our small interfering RNA (siRNA) delivery platforms.
Click on the links below to learn more about how RNAi can be used to "silence" gene expression and the production of proteins that cause or contribute to disease.
The Science of RNAi
An overview of RNA interference therapy and RISC-mediated RNA cleavage.
RNAi Therapeutics: How Do They Work?
This video highlights the MOA of RNAi therapeutics, and how small interfering RNA (siRNA) short oligonucleotides are used to harness the RNA-induced silencing complex (RISC) to silence gene expression. This resource is intended to be viewed in its entirety to support scientific exchange and is not intended as recommendations for clinical practice. For further information, please see RNAiScience.com to connect with a Medical Science Liaison, submit a medical information request, or access other Alnylam medical education resources.
Click below to learn about how different siRNA delivery platforms work.
Publication Date
Dec 2, 2020
Journal
Nucleic Acids Res.
Authors
Brown CR, Gupta S, Qin J et al.
Click here to learn more about how Alnylam is optimizing RNAi delivery.
