Alnylam & RNAi

Explore a library of educational resources about RNA interference (RNAi), the science behind Alnylam's FDA-approved products and clinical pipeline, and find out more about our small interfering RNA (siRNA) delivery platforms.

Ribosome making disease-causing protein with mRNA
Ribosome making disease-causing protein with mRNA

Click on the links below to learn more about how RNAi can be used to "silence" gene expression and the production of proteins that cause or contribute to disease.

Icon of PPT file

The Science of RNAi

An overview of RNA interference therapy and RISC-mediated RNA cleavage.

Icon of video player

RNAi Therapeutics: How Do They Work?

This video highlights the MOA of RNAi therapeutics, and how small interfering RNA (siRNA) short oligonucleotides are used to harness the RNA-induced silencing complex (RISC) to silence gene expression. This resource is intended to be viewed in its entirety to support scientific exchange and is not intended as recommendations for clinical practice. For further information, please see to connect with a Medical Science Liaison, submit a medical information request, or access other Alnylam medical education resources.

Click below to learn about how different siRNA delivery platforms work.

Publication Date

Dec 2, 2020


Nucleic Acids Res.


Brown CR, Gupta S, Qin J et al. 

Click here to learn more about how Alnylam is optimizing RNAi delivery.