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Search Results for "manifestation"

Alnylam is committed to providing the healthcare community with balanced, accurate, and high-quality information about our science, therapeutic areas, and products.

More than one search term is recommended to yield the most relevant results. By searching, you confirm that your query is unsolicited. 

For more information about our FDA-approved therapies, please see the Full Prescribing Information:

  • AMVUTTRA® (vutrisiran)
  • GIVLAARI® (givosiran)
  • ONPATTRO® (patisiran)
  • OXLUMO® (lumasiran)

HELIOS-A: Efficacy and safety of vutrisiran in patients with hATTR with polyneuropathy This link is a pdf
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Summary of the efficacy and safety results of vutrisiran compared to external placebo for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy, as published in the journal Amyloid, 2022.

ILLUMINATE Clinical Trial Program Overview This link is a pdf
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This infographic details the ILLUMINATE clinical trial program which investigates the treatment of Primary Hyperoxaluria Type 1 with lumasiran.

ATTR Screening and Carrier This link is a pdf
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ATTR Screening and Carrier 

Utility of Genetic Testing For Diagnosing hATTR Patients: Results from a European and Middle East Genetic Testing Program This link is a pdf
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The Journey to Diagnosis of Wild-Type ATTR Amyloidosis: A Path with Multisystem Involvement This link is a pdf
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Real-World Persistency on Tafamidis: An Analysis of US Insurance Claims Data This link is a pdf
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Design and Rationale of cAPPricorn-1, a Phase 2 Study of Mivelsiran in Patients With Cerebral Amyloid Angiopathy This link is a pdf
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The Journey to Diagnosis of ATTR Amyloidosis: Burden of Early Disease This link is a pdf
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Clinical Presentation and Treatment Landscape of Patients with Transthyretin Amyloidosis With Cardiomyopathy: A Real-world Study in Five European Countries and Japan This link is a pdf
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Renal Function and Isolated Kidney Transplant Outcomes in Primary Hyperoxaluria Type 1 Long-term Lumasiran Treatment This link is a pdf
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Impact of vutrisiran on outpatient worsening heart failure in patients with transthyretin amyloidosis with cardiomyopathy in the HELIOS-B trial This link is a pdf
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Insights from the phase 3 HELIOS-A study of vutrisiran in patients with hATTR-PN This link is a pdf
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This deck highlights data from the phase 3 HELIOS-A trial, including exploratory cardiac endpoints and post-hoc analyses.

Multiple-Dose Results from an Ongoing Phase 1 Study of Mivelsiran, an Investigational RNA Interference Therapeutic Targeting Amyloid-Beta Precursor Protein for Alzheimer’s Disease This link is a pdf
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Musculoskeletal manifestations in patients with ATTR amyloidosis: Evidence from real-world analyses and clinical trials This link is a pdf
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Vutrisiran In Patients With Transthyretin Amyloidosis with Cardiomyopathy In HELIOS-B Who Had Progressed On Tafamidis This link is a pdf
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Real-World Treatment Patterns in Participants with Transthyretin Amyloidosis with Polyneuropathy Enrolled in the ConTTRibute Registry This link is a pdf
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Effect of Patisiran Treatment in Patients with hATTR Amyloidosis with Cardiomyopathy and Polyneuropathy: Post-hoc Analysis of the APOLLO-B Study This link is a pdf
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Effect of Patisiran on Polyneuropathy and Cardiomyopathy in Patients with Hereditary Transthyretin Mediated (hATTR) Amyloidosis with a V122I or T60A Variant: A Phase 4 Observational Study This link is a pdf
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A Phase 2 Study Evaluating the Effects of Mivelsiran, an Investigational RNA Interference Therapeutic, on Hemorrhagic and Nonhemorrhagic Manifestations of Cerebral Amyloid Angiopathy This link is a pdf
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Musculoskeletal Manifestations Associated with ATTR Amyloidosis This link is a pdf
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This slide deck provides disease education on ATTR amyloidosis, focusing on the musculoskeletal manifestations associated with the disease and their importance for early diagnosis and patient care.

ATTR symptoms and manifestations early indicators This link is a pdf
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This deck highlights early indicators of ATTR and systemic manifestations.

Symptoms and Disease Burden of ATTR This link is a pdf
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Title: Symptoms and Disease Burden of ATTR External description: This slide deck provides an overview of the symptoms and disease burden of ATTR.

Explore ATTR-CM This link is a pdf
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This slide deck presents of overview of ATTR amyloidosis, covering pathophysiology, disease manifestations and the clinical burden of ATTR-CM.

Diagnosis of PH1 in CKD or Dialysis Patients This link is a pdf
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This handout informs the consequences of PH1 systemic manifestations due to declining kidney function and how to diagnose PH1.

Understanding AHP Infographic This link is a pdf
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This infographic about AHP describes the types of the disease, including AIP, pathophysiology, clinical presentation of acute and chronic symptoms, epidemiology, and diagnosis

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Intended for US healthcare professionals. This site is intended to provide balanced, evidence-based information to support scientific exchange. It is not intended to provide medical advice or recommendations for clinical practice.

Information about investigational therapeutics or investigational uses of approved products does not establish the safety or efficacy of these therapeutics or uses, and there is no guarantee of FDA approval.

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