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Search Results for "diagnosis"

Alnylam is committed to providing the healthcare community with balanced, accurate, and high-quality information about our science, therapeutic areas, and products.

More than one search term is recommended to yield the most relevant results. By searching, you confirm that your query is unsolicited. 

For more information about our FDA-approved therapies, please see the Full Prescribing Information:

  • AMVUTTRA® (vutrisiran)
  • GIVLAARI® (givosiran)
  • ONPATTRO® (patisiran)
  • OXLUMO® (lumasiran)

Descriptive Analysis of Real-World Enrollment Data of Pediatric and Adult Patients From a Global Primary Hyperoxaluria Type 1 Registry (BONAPH1DE) This link is a pdf
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Baseline characteristics from BONAPH1DE: A global, observational, longitudinal study of patients with primary hyperoxaluria type 1 This link is a pdf
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Characteristics of Patients Treated with Givosiran in ELEVATE, a Global Observational Longitudinal Registry of Patients with Acute Hepatic Porphyria This link is a pdf
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Characteristics of Patients Treated with Givosiran in ELEVATE, a Global Observational Longitudinal Registry of Patients with Acute Hepatic Porphyria This link is a pdf
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Kidney Survival in Patients with Primary Hyperoxaluria Type 1 Treated with Lumasiran Compared with Historical Controls This link is a pdf
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APOLLO Post-Hoc Analysis by Baseline Polyneuropathy Severity This link is a pdf
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A post-hoc analysis of the APOLLO trial was performed to evaluate the use of patisiran compared to placebo by baseline NIS quartile in patients with the the polyneuropathy of hATTR. This infographic summarizes the post-hoc analysis results, which were published in the journal Amyloid.

The symptom and quality-of-life burden of Acute Hepatic Porphyria (AHP): Evidence from a systematic literature review This link is a pdf
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Healthcare Resource Utilization and Costs Among Patient Segments with Acute Intermittent Porphyria: Analyses from a National Healthcare Database This link is a pdf
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Long-Term Efficacy and Safety in the 60-Month, Phase 3 ILLUMINATE-B Trial of Lumasiran in Infants and Young Children With Primary Hyperoxaluria Type 1 This link is a pdf
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Chronic symptoms reported by patients with acute hepatic porphyria in the POWER study in a subgroup analysis of nonrecurrent patients This link is a pdf
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Meta-regression analysis of the association between change in six minute walk distance and survival in transthyretin-mediated amyloidosis with cardiomyopathy This link is a pdf
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Natural History of Advanced Primary Hyperoxaluria Type 1: A Retrospective Study This link is a pdf
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Long-term clinical outcomes of patients with acute hepatic porphyria who were not attack-free after 6 months of givosiran treatment in a subgroup analysis of the phase 3 ENVISION study This link is a pdf
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HELIOS-A: Efficacy and safety of vutrisiran in patients with hATTR with polyneuropathy This link is a pdf
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Summary of the efficacy and safety results of vutrisiran compared to external placebo for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy, as published in the journal Amyloid, 2022.

Final 60-Month Efficacy, Safety, and Kidney Stone Outcomes of a Phase 3 Trial of Lumasiran for Primary Hyperoxaluria Type 1 in Infants and Young Children This link is a pdf
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Annualized attack rate reductions vs historical data and hemin use of patients with acute hepatic porphyria in phase 3 ENVISION trial who were not attack-free after 6 months of givosiran treatment This link is a pdf
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Long-Term Efficacy, Safety, and Growth Outcomes in the Phase 3 ILLUMINATE-B Trial of Lumasiran for Primary Hyperoxaluria Type 1 in Infants and Young Children This link is a pdf
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Clinical outcomes and hemin use of patients with acute hepatic porphyria in the phase 3 ENVISION study who were not attack-free after 6 months of givosiran treatment This link is a pdf
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Neurofilament Light Chain as a Biomarker in Hereditary Transthyretin-Mediated Amyloidosis: 36-Month Data from the Patisiran Global Open-Label Extension This link is a pdf
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EXPLORE B post hoc analysis of chronic symptoms in patients with acute hepatic porphyria This link is a pdf
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Clinical outcomes and hemin use of patients with acute hepatic porphyria in the phase 3 ENVISION study who were not attack-free after 6 months of givosiran treatment This link is a pdf
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The Journey to Diagnosis of ATTR Amyloidosis: Burden of Early Disease This link is a pdf
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The Journey to Diagnosis of Wild-Type ATTR Amyloidosis: A Path with Multisystem Involvement This link is a pdf
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Alnylam Act®: Effectiveness of Genetic Testing in Establishing a Diagnosis in Patients with Suspicion of Hereditary Transthyretin Amyloidosis This link is a pdf
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ATTRv-PN Expert Opinion Slide Deck This link is a pdf
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Recommendations from a panel of experts for the diagnosis and treatment of hereditary transthyretin amyloidosis with polyneuropathy in the United States.

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Intended for US healthcare professionals. This site is intended to provide balanced, evidence-based information to support scientific exchange. It is not intended to provide medical advice or recommendations for clinical practice.

Information about investigational therapeutics or investigational uses of approved products does not establish the safety or efficacy of these therapeutics or uses, and there is no guarantee of FDA approval.

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