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Search Results for "Alnylam"

Alnylam is committed to providing the healthcare community with balanced, accurate, and high-quality information about our science, therapeutic areas, and products.

More than one search term is recommended to yield the most relevant results. By searching, you confirm that your query is unsolicited. 

For more information about our FDA-approved therapies, please see the Full Prescribing Information:

  • AMVUTTRA® (vutrisiran)
  • GIVLAARI® (givosiran)
  • ONPATTRO® (patisiran)
  • OXLUMO® (lumasiran)

ILLUMINATE Clinical Trial Program Overview This link is a pdf
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This infographic details the ILLUMINATE clinical trial program which investigates the treatment of Primary Hyperoxaluria Type 1 with lumasiran.

Healthcare resource utilization for patients with transthyretin amyloid cardiomyopathy: A real-world study in Europe, Canada and Japan This link is a pdf
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Outpatient Heart Failure Worsening in Patients with Cardiac Transthyretin Amyloidosis: Results from the APOLLO-B Trial This link is a pdf
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Kidney Function and Isolated Kidney Transplant Outcomes in Primary Hyperoxaluria Type 1 Treated With Long-term Lumasiran This link is a pdf
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Real-world experience with therapeutics for ATTR in the Canadian population This link is a pdf
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Natural History of Advanced Primary Hyperoxaluria Type 1: A Retrospective Study This link is a pdf
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Left Atrial Strain and Clinical Outcomes in Transthyretin Amyloidosis with Cardiomyopathy: Insights from the HELIOS-B Trial on Vutrisiran Efficacy This link is a pdf
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Right Ventricular Free Wall Strain and Clinical Outcomes in Transthyretin Amyloid Cardiomyopathy and Effect of Vutrisiran: The HELIOS-B Study This link is a pdf
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Efficacy of vutrisiran in patients with transthyretin amyloidosis with cardiomyopathy by baseline health status and quality of life This link is a pdf
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Long-term Efficacy and Safety of Lumasiran in Patients With Primary Hyperoxaluria Type 1: Final Analysis of the ILLUMINATE-A Trial This link is a pdf
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Meta-regression analysis of the association between change in six minute walk distance and survival in transthyretin-mediated amyloidosis with cardiomyopathy This link is a pdf
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APOLLO Post-Hoc Analysis by Baseline Polyneuropathy Severity This link is a pdf
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A post-hoc analysis of the APOLLO trial was performed to evaluate the use of patisiran compared to placebo by baseline NIS quartile in patients with the the polyneuropathy of hATTR. This infographic summarizes the post-hoc analysis results, which were published in the journal Amyloid.

Impact of Vutrisiran on Activities of Daily Living and Functional Status in Patients with hATTR Amyloidosis This link is a pdf
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Patient Experience with Acute Hepatic Porphyria Before and After Long-Term Givosiran Treatment: A Qualitative Interview Study This link is a pdf
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Evidence of Fewer Gastrointestinal Events in ATTR-CM Patients Treated with Vutrisiran Compared with Placebo: Analysis from HELIOS-B This link is a pdf
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Targeting Glycolate Oxidase for the Treatment of Primary Hyperoxaluria Type 1: Development and Clinical Characterization of Lumasiran, an RNAi Therapeutic This link is a pdf
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HELIOS-A: Efficacy and safety of vutrisiran in patients with hATTR with polyneuropathy This link is a pdf
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Summary of the efficacy and safety results of vutrisiran compared to external placebo for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy, as published in the journal Amyloid, 2022.

RNAi Therapy in ATTRv Amyloidosis with Polyneuropathy (HELIOS-A): Patient-reported Experiences and Preferences This link is a pdf
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Vutrisiran Improved Outcomes Versus Placebo in Patients with Transthyretin Amyloidosis with Cardiomyopathy and Severe Chronic Kidney Disease: Post Hoc Analysis of HELIOS-B This link is a pdf
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Impact of Baseline Polyneuropathy Severity on Vutrisiran Treatment Response in the Phase 3 HELIOS-A Study This link is a pdf
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Baseline characteristics from BONAPH1DE: A global, observational, longitudinal study of patients with primary hyperoxaluria type 1 This link is a pdf
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Long-term treatment with lumasiran: final results from the phase 2 open-label extension study This link is a pdf
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Long-Term Efficacy and Safety in the 60-Month, Phase 3 ILLUMINATE-B Trial of Lumasiran in Infants and Young Children With Primary Hyperoxaluria Type 1 This link is a pdf
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Alnylam Act®: Effectiveness of Genetic Testing in Establishing a Diagnosis in Patients with Suspicion of Hereditary Transthyretin Amyloidosis This link is a pdf
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Cardiovascular Morbidity and Mortality Among ATTR-CM Patients Treated with Tafamidis in the US This link is a pdf
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This site is intended for US healthcare professionals.
© 2026 Alnylam Pharmaceuticals, Inc. All rights reserved.
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Intended for US healthcare professionals. This site is intended to provide balanced, evidence-based information to support scientific exchange. It is not intended to provide medical advice or recommendations for clinical practice.

Information about investigational therapeutics or investigational uses of approved products does not establish the safety or efficacy of these therapeutics or uses, and there is no guarantee of FDA approval.

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