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Search Results for "manifestation"

Alnylam is committed to providing the healthcare community with balanced, accurate, and high-quality information about our science, therapeutic areas, and products.

More than one search term is recommended to yield the most relevant results. By searching, you confirm that your query is unsolicited. 

For more information about our FDA-approved therapies, please see the Full Prescribing Information:

  • AMVUTTRA® (vutrisiran)
  • GIVLAARI® (givosiran)
  • ONPATTRO® (patisiran)
  • OXLUMO® (lumasiran)

Exploratory Analyses from APOLLO-B, A Phase 3 Study of Patisiran in Patients with ATTR Amyloidosis with Cardiomyopathy This link is a pdf
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HELIOS A: Study of Vutrisiran in Patients with hATTR Amyloidosis This link is a pdf
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Primary Results from APOLLO-B, A Phase 3 Study of Patisiran in Patients with Transthyretin-Mediated Amyloidosis with Cardiomyopathy This link is a pdf
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Risk of Seizures Among Patients with Cerebral Amyloid Angiopathy – a Nationwide Retrospective Cohort Study in the United States This link is a pdf
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Diagnosing AHP Infographic This link is a pdf
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This infographic discusses the clinical and demographic presentation of an AHP patient and how to assess for AHP diagnosis.

Targeting Cerebral Amyloid Angiopathy at its Source: An Amyloid Beta Precursor Protein-Targeted siRNA Reduced Vascular Amyloid Beta and Hemorrhage in Rodent Models This link is a pdf
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Understanding ATTR Amyloidosis This link is a pdf
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Understanding ATTR amlyloidosis: This slide deck highlights an overview of ATTR amyloidosis pathophysiology, symptom onset and prevalence

ATTR-CM HELIOS-B Data Summary This link is a pdf
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ATTR-CM HELIOS-B Data Summary deck provides a comprehensive overview of the HELIOS-B results. Also includes information on ATTR-CM and the MOA of RNAi therapeutics.

Phase 3 HELIOS-B Study Rationale This link is a pdf
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This slide deck highlights the Phase 3 trial design for HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy.

FRENCH: HELIOS-A : Analyse randomisée de 18 mois d'extension du vutrisiran chez des patients atteints d'amylose héréditaire à transthyrétine avec polyneuropathie This link is a pdf
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ATTR Disease Management This link is a pdf
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This deck highlights management and monitoring of patients with ATTR.

RNAi Data Navigator: Focus on Vutrisiran This link is a pdf
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This interactive PDF provides an overview of ATTR-CM and RNAi therapeutics, and offers a deep dive into the vutrisiran data in ATTR-CM from the HELIOS-B trial, including the primary and additional analyses. Alnylam's ongoing commitment to ATTR amyloidosis is reflected in a summary of the current pipeline and TRITON-CM study design.

Patisiran: Patients with Heart Transplant This link is a pdf
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Standard response letter on patisiran and use in patients with heart transplant.

Patisiran: Pregnancy and Lactation This link is a pdf
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Standard response letter on patisiran and pregnancy & lactation. This letter contains information on preclinical toxicology studies and the APOLLO, APOLLO-B, and HELIOS-A studies.

Diagnosing PH1 Infographic This link is a pdf
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This infographic discusses the clinical and demographic presentation of a PH1 patient and how to assess for PH1 diagnosis

Insights from the HELIOS-A Study This link is a pdf
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This deck highlights data from the Phase 3 HELIOS-A trial of vutrisiran in patients with hATTR-PN.

Lumasiran Clinical Program Overview This link is a pdf
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This infographic details the lumasiran clinical program (including ILLUMINATE) which investigates the treatment of primary hyperoxaluria type 1 with lumasiran.

For further information regarding your request, please connect with us by reaching out to your local Medical Science Liaison or contacting our Medical Information team.

This site is intended for US healthcare professionals.
© 2026 Alnylam Pharmaceuticals, Inc. All rights reserved.
MED-US-ALL-2400001

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Intended for US healthcare professionals. This site is intended to provide balanced, evidence-based information to support scientific exchange. It is not intended to provide medical advice or recommendations for clinical practice.

Information about investigational therapeutics or investigational uses of approved products does not establish the safety or efficacy of these therapeutics or uses, and there is no guarantee of FDA approval.

Alnylam does not recommend or suggest use of its products in any manner inconsistent with the approved Prescribing Information.

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