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Search Results for "Alnylam"

Alnylam is committed to providing the healthcare community with balanced, accurate, and high-quality information about our science, therapeutic areas, and products.

More than one search term is recommended to yield the most relevant results. By searching, you confirm that your query is unsolicited. 

For more information about our FDA-approved therapies, please see the Full Prescribing Information:

  • AMVUTTRA® (vutrisiran)
  • GIVLAARI® (givosiran)
  • ONPATTRO® (patisiran)
  • OXLUMO® (lumasiran)

Vutrisiran Treatment in Patients with Transthyretin Amyloidosis with Cardiomyopathy This link is a pdf
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This asset represents the HELIOS-B primary results, published in the New England Journal of Medicine, in slide deck form.

Givosiran: Latex Content This link is a pdf
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Standard response letter on the latex content of givosiran vial.

Lumasiran: Pregnancy and Lactation This link is a pdf
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Standard response letter on lumasiran and pregnancy and lactation in the Phase 2 OLE and Phase 3 ILLUMINATE studies.

HELIOS-A: 9-Month Results from the Randomized Treatment Extension Period of Vutrisiran in Patients with Hereditary Transthyretin-Mediated Amyloidosis with Polyneuropathy This link is a pdf
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Lumasiran: ILLUMINATE-B Study Overview This link is a pdf
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Standard response letter on the lumasiran phase 3 clinical study ILLUMINATE-B, a study evaluating the efficacy and safety of lumasiran in infants and children less than 6 years old with PH1.

Kidney Function and Isolated Kidney Transplant Outcomes in Primary Hyperoxaluria Type 1 Treated with Long-term Lumasiran This link is a pdf
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Effect of Patisiran on Polyneuropathy and Cardiomyopathy in Patients with Hereditary Transthyretin Mediated (hATTR) Amyloidosis with a V122I or T60A Variant: A Phase 4 Observational Study This link is a pdf
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Vutrisiran: Orthostatic Hypotension This link is a pdf
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Standard response letter on the quantitative effect of vutrisiran on orthostatic hypotension in the HELIOS-A study, assessed using the postural blood pressure component of mNIS+7.

Patisiran: Use in Patients with hATTR Amyloidosis with Cardiomyopathy and Polyneuropathy This link is a pdf
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Standard response letter on the use of patisiran in patients with hATTR and mixed phenotype from the APOLLO-B study.

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Intended for US healthcare professionals. This site is intended to provide balanced, evidence-based information to support scientific exchange. It is not intended to provide medical advice or recommendations for clinical practice.

Information about investigational therapeutics or investigational uses of approved products does not establish the safety or efficacy of these therapeutics or uses, and there is no guarantee of FDA approval.

Alnylam does not recommend or suggest use of its products in any manner inconsistent with the approved Prescribing Information.

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