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Alnylam is committed to providing the healthcare community with balanced, accurate, and high-quality information about our science, therapeutic areas, and products.

More than one search term is recommended to yield the most relevant results. By searching, you confirm that your query is unsolicited. 

For more information about our FDA-approved therapies, please see the Full Prescribing Information:

  • AMVUTTRA® (vutrisiran)
  • GIVLAARI® (givosiran)
  • ONPATTRO® (patisiran)
  • OXLUMO® (lumasiran)

Effect of RNAi Therapeutics Patisiran and Vutrisiran on Orthostatic Hypotension Due to Dysautonomia in Patients with Hereditary Transthyretin-Mediated Amyloidosis with Polyneuropathy This link is a pdf
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Outpatient Heart Failure Worsening in Patients with Cardiac Transthyretin Amyloidosis: Results from the APOLLO-B Trial This link is a pdf
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Efficacy and Safety of Givosiran in Patients with Acute Hepatic Porphyria: 36-Month Results of the Phase 3 ENVISION Randomized Clinical Trial This link is a pdf
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Healthcare resource utilization for patients with transthyretin amyloid cardiomyopathy: A real-world study in Europe, Canada and Japan This link is a pdf
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ILLUMINATE Clinical Trial Program Overview This link is a pdf
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This infographic details the ILLUMINATE clinical trial program which investigates the treatment of Primary Hyperoxaluria Type 1 with lumasiran.

Real-world experience with therapeutics for ATTR in the Canadian population This link is a pdf
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Impact of Baseline Polyneuropathy Severity on Vutrisiran Treatment Response in the Phase 3 HELIOS-A Study This link is a pdf
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ENVISION study EQ-5D analysis to assess relationship between annualized attack rate with expanded criteria and chronic symptoms in patients with acute hepatic porphyria This link is a pdf
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Dimension analysis of ENVISION study EQ-5D data to assess relationship between annualized attack rate and chronic symptoms in patients with acute hepatic porphyria This link is a pdf
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NfL Levels Significantly Decrease in Response to Treatment with Patisiran or Vutrisiran in hATTR Amyloidosis with Polyneuropathy This link is a pdf
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Long-term treatment with lumasiran: final results from the phase 2 open-label extension study This link is a pdf
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Vutrisiran Improved Outcomes Versus Placebo in Patients with Transthyretin Amyloidosis with Cardiomyopathy and Severe Chronic Kidney Disease: Post Hoc Analysis of HELIOS-B This link is a pdf
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Effectiveness of Patisiran Following Switch From Tafamidis for the Treatment of Hereditary Transthyretin Mediated (hATTR) Amyloidosis with Polyneuropathy This link is a pdf
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HELIOS-A: Impact of Vutrisiran on Quality of Life and Functional Status in Hereditary Transthyretin Mediated Amyloidosis with Polyneuropathy This link is a pdf
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History of Polyneuropathy and Musculoskeletal Manifestations in Patients with Transthyretin-Mediated Amyloidosis with Cardiomyopathy in APOLLO-B This link is a pdf
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Connecting the Musculoskeletal Dots to Identify the Early Manifestations of Transthyretin-Mediated (ATTR) Amyloidosis This link is a pdf
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The V122I Mutation in Hereditary Transthyretin-Mediated Amyloidosis is Significantly Associated with Polyneuropathy This link is a pdf
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Hereditary ATTR Amyloidosis: A Closer Look at the V122I Variant External This link is a pdf
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V122I is the most common variant of hATTR amyloidosis in the United States and is most prevalent in patients of African American descent. Compared to other variants, patients with the V122I variant experience significant disease burden and poorer outcomes.

Baseline Characteristics of Patients with Transthyretin Cardiac Amyloidosis Enrolled in the Patisiran Expanded Access Program This link is a pdf
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ATTR Screening and Carrier This link is a pdf
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ATTR Screening and Carrier 

Impact of Long-Term Blood Pressure Variability on Adverse Cardiovascular Outcomes in High- and Low-Risk Populations This link is a pdf
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Utility of Genetic Testing For Diagnosing hATTR Patients: Results from a European and Middle East Genetic Testing Program This link is a pdf
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Patient demographics and clinical characteristics at enrolment in ELEVATE, an international registry of acute hepatic porphyria This link is a pdf
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Health-related quality of life for patients with transthyretin amyloid cardiomyopathy: A real-world study in Europe, Canada and Japan This link is a pdf
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Long-term clinical outcomes of patients with acute hepatic porphyria who were not attack-free after 6 months of givosiran treatment in a subgroup analysis of the phase 3 ENVISION study This link is a pdf
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Intended for US healthcare professionals. This site is intended to provide balanced, evidence-based information to support scientific exchange. It is not intended to provide medical advice or recommendations for clinical practice.

Information about investigational therapeutics or investigational uses of approved products does not establish the safety or efficacy of these therapeutics or uses, and there is no guarantee of FDA approval.

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