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Transthyretin Amyloidosis (ATTR)

Learn more about the underlying pathophysiology of ATTR and explore current approaches to diagnosing and managing ATTR‑CM and hATTR‑PN

Additional Resources

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Video

Pathophysiology of ATTR

Watch the full mechanism of disease video for a comprehensive overview of the pathophysiology of ATTR

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Presentation

Explore ATTR‑CM

An overview of the pathophysiology, disease burden, recognition, and diagnosis of ATTR‑CM

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Presentation

Hereditary ATTR Amyloidosis: A Closer Look at the V122I Variant

An overview of ATTR, with a focus on the prevalence, prognosis, burden, and clinical presentation of the V122I variant

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Introduction

Video

ATTR Introduction

This video highlights the MoD of ATTR and how TTR dissociates into pathogenic monomers and fragments

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ATTR overview

Video

ATTR Overview

This video highlights the MoD of ATTR, showing how TTR dissociates into pathogenic monomers and fragements, which can misfold and aggregate as amyloid fibrils, ultimately accumlating in tissues and organs

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Video

ATTR Manifestations

This video highlights the MoD of ATTR which can manifest as cardiomyopathy, polyneuropathy, and gastrointestinal and ocular disturbances

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MED-US-TTR-2600018