AMVUTTRA® (vutrisiran)

Explore a range of clinical and educational resources related to the use of vutrisiran in adult patients with the polyneuropathy of hereditary ATTR (hATTR, also known as ATTRv) amyloidosis or with the cardiomyopathy of wild-type or hereditary ATTR amyloidosis

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Find out more about the clinical data from the HELIOS‑A study in patients with hereditary transthyretin amyloidosis with polyneuropathy (hATTR‑PN) using the interactive tool. Navigate through individual outcomes using the menu and the forward and backward controls. For optimal viewing, enter full-screen mode

Insights from the HELIOS‑A Study - thumbnail

Data from the Phase 3 HELIOS‑A trial of vutrisiran in patients with hATTR‑PN

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Transthyretin Amyloidosis (ATTR)

Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial

Amyloid

Author(s)

David Adams, Ivailo Tournev, Mark Taylor, et al

July 2022

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Transthyretin Amyloidosis (ATTR)

Vutrisiran in Transthyretin Amyloidosis: A Pooled Safety Analysis of HELIOS‑A and HELIOS‑B

JACC: Advances

Author(s)

Ronald M. Witteles, Pablo Garcia-Pavia, Caroline Morbach, et al

August 2025

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Transthyretin Amyloidosis (ATTR)

Impact of Baseline Neuropathy Severity on Vutrisiran Treatment Response in the Phase 3 HELIOS‑A Study

Neurology and Therapy

Author(s)

Marco Luigetti, Dianna Quan, John L. Berk, et al

March 2024

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Transthyretin Amyloidosis (ATTR)

Learn more about ATTR

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Additional Resources

Learn more about the vutrisiran data and RNAi therapeutics

MED-US-VUTRI-2600004

Disease & Therapeutic Areas | Therapies

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AMVUTTRA® (vutrisiran)

HELIOS‑A: Clinical Study Data

Additional Resources

Insights from the HELIOS‑A Study

Publications

Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial

Vutrisiran in Transthyretin Amyloidosis: A Pooled Safety Analysis of HELIOS‑A and HELIOS‑B

Impact of Baseline Neuropathy Severity on Vutrisiran Treatment Response in the Phase 3 HELIOS‑A Study

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